Price range: $268.00 through $328.00
Background:
This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
| Size | 50μL/100μL |
| Target | AHSP |
| Reactivity | Human, Mouse |
| Applications | IHC, IF |
| MW(Calculated) | 11kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AHSP AA range: 1-51 |
| Specificity | This antibody detects endogenous levels of AHSP at Human/Mouse |
| Gene Name | AHSP EDRF ERAF |
| Protein Name | AHSP |
| Other Name | |
| Species | Human |
| Gene ID | 51327 |
| Uniprot | Q9NZD4, |
| Species.1 | Mouse |
| Gene ID.1 | 170812 |
| Uniprot.1 | Q9CY02 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Expressed in blood and bone marrow. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.,induction:By GATA-1 during erythroid maturation.,similarity:Belongs to the AHSP family.,subunit:Monomer. Forms an heterodimer with free alpha-hemoglobin. Does not bind beta-hemoglobin nor alpha(2)beta(2) hemoglobin A.,tissue specificity:Expressed in blood and bone marrow., |
