Name: AKAP 10 Polyclonal Antibody
SKU: WP10991
Price: 268 USD
Availability: InStock

AKAP 10 Polyclonal Antibody

Ucallm_WP10991-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP10991-100

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Product details

Background:

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012],

Specifications

Size	50μL/100μL
Target	AKAP 10
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	73kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human AKAP10. AA range:10-59
Specificity	AKAP 10 Polyclonal Antibody detects endogenous levels of AKAP 10 protein.
Gene Name	AKAP10
Protein Name	A-kinase anchor protein 10 mitochondrial
Other Name	AKAP10; / A-kinase anchor protein 10; / mitochondrial; / AKAP-10; / Dual specificity A kinase-anchoring protein 2; / D-AKAP-2; / Protein kinase A-anchoring protein 10; / PRKA10
Species	Human
Gene ID	11216
Uniprot	O43572,
Species.1	Mouse
Gene ID.1	56697
Uniprot.1	O88845
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Mitochondrion . Membrane . Cytoplasm . Predominantly mitochondrial but also membrane associated and cytoplasmic.
Tissue Expression	Brain,Lung,
Signaling_pathway
Research Areas
Function	Domain:RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.,Function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.,similarity:Contains 2 RGS domains.,subcellular location:Predominantly mitochondrial but also membrane associated and cytoplasmic.,