Name: Aldose Reductase Monoclonal Antibody
SKU: WM0474
Price: 268 USD
Availability: InStock

Aldose Reductase Monoclonal Antibody

Ucallm_WM0474-50

Price range: $268.00 through $328.00

Size

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50μl

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SKU: WM0474-50

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Product details

Background:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009],

Specifications

Size	50μL/100μL
Target	AKR1B1
Reactivity	Human, Mouse, Dog
Applications	WB
MW(Calculated)	36kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000-1:2000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	12D6
Immunogen	Purified recombinant human Aldose Reductase protein fragments expressed in E.coli.
Specificity	Aldose Reductase Monoclonal Antibody detects endogenous levels of Aldose Reductase protein.
Gene Name	AKR1B1
Protein Name	Aldose reductase
Other Name	AKR1B1; / ALDR1; / Aldose reductase; / AR; / Aldehyde reductase; / Aldo-keto reductase family 1 member B1
Species	Human
Gene ID	231
Uniprot	P15121,
Species.1	Mouse
Gene ID.1	11677
Uniprot.1	P45376,
Species.2	Rat
Gene ID.2	24192
Uniprot.2	P07943
Cellular Localization	Cytoplasm.
Tissue Expression	Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
Signaling_pathway
Research Areas	>>Pentose and glucuronate interconversions; / >>Fructose and mannose metabolism; / >>Galactose metabolism; / >>Glycerolipid metabolism; / >>Folate biosynthesis; / >>Metabolic pathways
Function	Catalytic activity:Alditol + NAD(P)(+) = aldose + NAD(P)H.,Disease:In diabetes and galactosemia, increased AR activity leads to high levels of sorbitol and galactitol, respectively, in the cells of many tissues. Accumulation of sugar alcohols has been shown to cause osmotic cataracts in the lens. AR is also thought to play a key role in diabetic complications of three other target tissues, namely, nerve, kidney and retina.,enzyme regulation:Cys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis.,Function:Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.,similarity:Belongs to the aldo/keto reductase family.,subunit:Monomer.,tissue specificity:Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.,

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Aldose Reductase Monoclonal Antibody

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Aldose Reductase Monoclonal Antibody

Product details

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