SKU: WP11014 Categories: ,

Aldose Reductase Polyclonal Antibody

$499.00

SKU: WP11014-100
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Product details

Background:

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009],

Specifications

TargetAKR1B1
ReactivityHuman, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)36kD
Host SpeciesRabbit
IsotypeIgG
Conjugate
ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
CompositionLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification ProcessThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage Condition-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human AKR1B1. AA range:241-290
Sequence
SpecificityAldose Reductase Polyclonal Antibody detects endogenous levels of Aldose Reductase protein.
Gene NameAKR1B1
Protein NameAldose reductase
AliasAKR1B1;ALDR1;Aldose reductase;AR;Aldehyde reductase;Aldo-keto reductase family 1 member B1
Organism-1Human
Gene ID-1231
SwissProt-1P15121
Organism-2Mouse
Gene ID-2
SwissProt-2P45376
Organism-3Rat
Gene ID-324192
SwissProt-3P07943
Organism-4
Gene ID-4
SwissProt-4
Cellular LocalizationCytoplasm.
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