Price range: $268.00 through $328.00
Background:
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015],
| Size | 50μL/100μL |
| Target | ANFC |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 13kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 65-95 |
| Specificity | ANFC Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | NPPC CNP2 |
| Protein Name | C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53] |
| Other Name | |
| Species | Human |
| Gene ID | 4880 |
| Uniprot | P23582, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61839, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P55207 |
| Cellular Localization | Secreted. |
| Tissue Expression | [CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level). |
| Signaling_pathway | Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | >>cGMP-PKG signaling pathway; / >>Vascular smooth muscle contraction; / >>Fluid shear stress and atherosclerosis |
| Function | Function:Vasorelaxant activity. Has a cGMP-stimulating activity.,similarity:Belongs to the natriuretic peptide family., |
