ANKLE2 rabbit pAb
Ucallm_WP8531-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | ANKLE2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 103kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ANKLE2 |
| Specificity | This antibody detects endogenous levels of ANKLE2 at Human, Mouse,Rat |
| Gene Name | ANKLE2 KIAA0692 LEM4 |
| Protein Name | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) |
| Other Name | |
| Species | Human |
| Gene ID | 23141 |
| Uniprot | Q86XL3, |
| Species.1 | Mouse |
| Gene ID.1 | 71782 |
| Uniprot.1 | Q6P1H6, |
| Species.2 | Rat |
| Gene ID.2 | 360829 |
| Uniprot.2 | Q7TP65 |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type III membrane protein . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit . Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly . May regulate nuclear localization of VRK1 in non-dividing cells . It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex . Involved in brain development . |
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