Name: U-Blot® Annexin II Rabbit mAb
SKU: WR4876
Price: 268 USD
Availability: InStock

U-Blot® Annexin II Rabbit mAb

Ucallm_WR4876-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR4876-50

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Product details

Background:This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Annexin II
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	39kD
MW(Observed)	39kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:2000-1:10000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1046R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	ANXA2
Protein Name	Annexin A2
Other Name	ANXA2; / ANX2; / ANX2L4; / CAL1H; / LPC2D; / Annexin A2; / Annexin II; / Annexin-2; / Calpactin I heavy chain; / Calpactin-1 heavy chain; / Chromobindin-8; / Lipocortin II; / Placental anticoagulant protein IV; / PAP-IV; / Protein I; / p36
Species	Human
Gene ID	302
Uniprot	P07355,
Species.1	Mouse
Gene ID.1	12306
Uniprot.1	P07356,
Species.2	Rat
Gene ID.2	56611
Uniprot.2	Q07936
Cellular Localization	Secreted, extracellular space, extracellular matrix, basement membrane . Melanosome . In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
Tissue Expression	Brain,Colon,Colon adenocarcinoma,Epithelium,Osteosarcoma,Pancreas,Placenta,Prostate,Skin,Te
Signaling_pathway
Research Areas	>>Salmonella infection
Function	Domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,Function:Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.,miscellaneous:It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.,online information:Red velvet - Issue 86 of September 2007,PTM:Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,subcellular location:In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.,subunit:Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF.,