SKU: WP2573 Categories: ,

ANX13 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2573-100
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Product details

Background:

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetANX13
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)34kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityANX13 Polyclonal Antibody detects endogenous levels of protein.
Gene NameANXA13 ANX13
Protein NameAnnexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA)
Other Name
SpeciesHuman
Gene ID312
UniprotP27216,
Species.1Mouse
Gene ID.1
Uniprot.1Q99JG3
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationApical cell membrane . Cell membrane; Lipid-anchor . Cytoplasmic vesicle . Myristoylation anchors the protein to the membrane, but the protein displays also calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946). .
Tissue ExpressionDetected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum.
Signaling_pathway
Research Areas
FunctionDomain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,subcellular location:Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.,tissue specificity:Gut specific.,
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