Name: IL-12A Polyclonal Antibody
SKU: WP12806
Price: 268 USD
Availability: InStock

Product details

Background:

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	IL-12A
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	25kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC:1:50-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human IL-12A. AA range:16-65
Specificity	IL-12A Polyclonal Antibody detects endogenous levels of IL-12A protein.
Gene Name	IL12A
Protein Name	Interleukin-12 subunit alpha
Other Name	IL12A; / NKSF1; / Interleukin-12 subunit alpha; / IL-12A; / Cytotoxic lymphocyte maturation factor 35 kDa subunit; / CLMF p35; / IL-12 subunit p35; / NK cell stimulatory factor chain 1; / NKSF1
Species	Human
Gene ID	3592
Uniprot	P29459,
Species.1	Mouse
Gene ID.1	16159
Uniprot.1	P43431,
Species.2	Rat
Gene ID.2	84405
Uniprot.2	Q9R103
Cellular Localization	Secreted .
Tissue Expression	Brain,Placenta,
Signaling_pathway	Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Immune disease >> Inflammatory bowel disease;Human Diseases >> Immune disease >> Allograft rejection;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>Toll-like receptor signaling pathway; / >>RIG-I-like receptor signaling pathway; / >>C-type lectin receptor signaling pathway; / >>JAK-STAT signaling pathway; / >>Th1 and Th2 cell differentiation; / >>Alcoholic liver disease; / >>Type I diabetes mellitus; / >>Pertussis; / >>Legionellosis; / >>Leishmaniasis; / >>Chagas disease; / >>African trypanosomiasis; / >>Malaria; / >>Toxoplasmosis; / >>Amoebiasis; / >>Tuberculosis; / >>Measles; / >>Influenza A; / >>Herpes simplex virus 1 infection; / >>Coronavirus disease - COVID-19; / >>Pathways in cancer; / >>Inflammatory bowel disease; / >>Allograft rejection; / >>Lipid and atherosclerosis
Function	Function:Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.,online information:Interleukin-12 entry,similarity:Belongs to the IL-6 superfamily.,subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.,

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IL-12A Polyclonal Antibody

Product details

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IL-12A Polyclonal Antibody

Product details

Specifications

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