SKU: WR4860 Categories: ,

U-Blot® ANXA5 Rabbit mAb

Price range: $268.00 through $328.00

SKU: WR4860-50
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Product details

Background:The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetANXA5
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)36kD
MW(Observed)36kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:2000-1:10000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRM1024R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NameANXA5 ANX5 ENX2 PP4
Protein NameAnnexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CBP-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)
Other Name
SpeciesHuman
Gene ID308
UniprotP08758,
Species.1Mouse
Gene ID.1
Uniprot.1P48036,
Species.2Rat
Gene ID.2
Uniprot.2P14668
Cellular Localizationintracellular,cytoplasm,focal adhesion,external side of plasma membrane,membrane,extracellular exosome,endothelial microparticle,
Tissue ExpressionAdipocyte,Epithelium,Lung,Melanoma,Muscle,Ovary,Placenta,Skin,
Signaling_pathway
Research Areas
FunctionCaution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Caution:This protein has been independently sequenced by at least seven groups under different names.,Domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,Function:This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,subunit:Monomer. Binds ATRX and EIF5B.,
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