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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/AOC3 Polyclonal Antibody
SKU: WP2789 Categories: ,

AOC3 Polyclonal Antibody

Ucallm_WP2789-50

Price range: $268.00 through $328.00

SKU: WP2789-100
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Product details

Background:

This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013],

Specifications

Size50μL/100μL
TargetAOC3
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)83kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 510-590
SpecificityAOC3 Polyclonal Antibody detects endogenous levels of protein.
Gene NameAOC3 VAP1
Protein NameMembrane primary amine oxidase (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1)
Other Name
SpeciesHuman
Gene ID8639
UniprotQ16853,
Species.1Mouse
Gene ID.1
Uniprot.1O70423,
Species.2Rat
Gene ID.2
Uniprot.2O08590
Cellular LocalizationCell membrane; Single-pass type II membrane protein .
Tissue ExpressionStrongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung.
Signaling_pathway
Research Areas>>Glycine, serine and threonine metabolism; / >>Tyrosine metabolism; / >>Phenylalanine metabolism; / >>beta-Alanine metabolism; / >>Metabolic pathways
FunctionCatalytic activity:RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).,cofactor:Binds 1 copper ion per subunit.,cofactor:Binds 2 calcium ions per subunit.,cofactor:Contains 1 topaquinone per subunit.,Function:Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity.,PTM:N- and O-glycosylated.,PTM:Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.,similarity:Belongs to the copper/topaquinone oxidase family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed at lower levels in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis.,
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