AP4A rabbit pAb
Ucallm_WP16802-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011],
Specifications
| Size | 50μL/100μL |
| Target | AP4A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 16kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AP4A AA range: 93-143 |
| Specificity | This antibody detects endogenous levels of AP4A at Human/Mouse/Rat |
| Gene Name | NUDT2 APAH1 |
| Protein Name | AP4A |
| Other Name | |
| Species | Human |
| Gene ID | 318 |
| Uniprot | P50583, |
| Species.1 | Mouse |
| Gene ID.1 | 66401 |
| Uniprot.1 | P56380, |
| Species.2 | Rat |
| Gene ID.2 | 297998 |
| Uniprot.2 | Q6PEC0 |
| Cellular Localization | mitochondrial matrix, |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Purine metabolism; / >>Pyrimidine metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP.,cofactor:Divalent ions.,Function:Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.,similarity:Belongs to the Nudix hydrolase family., |
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