Name: APC4 Polyclonal Antibody
SKU: WP2212
Price: 268 USD
Availability: InStock

APC4 Polyclonal Antibody

Ucallm_WP2212-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP2212-100

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Product details

Background:

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013],

Specifications

Size	50μL/100μL
Target	APC4
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	88kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	APC4 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	ANAPC4 APC4
Protein Name	Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4)
Other Name
Species	Human
Gene ID	29945
Uniprot	Q9UJX5,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q91W96
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Amygdala,Placenta,Testis,
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cell cycle
Research Areas	>>Cell cycle; / >>Oocyte meiosis; / >>Ubiquitin mediated proteolysis; / >>Progesterone-mediated oocyte maturation; / >>Human T-cell leukemia virus 1 infection
Function	Function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC4 family.,subunit:The APC/C is composed of at least 11 subunits.,