ApoA-IV Monoclonal Antibody
Ucallm_WM0026-50
Price range: $268.00 through $328.00
Product details
Background:
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | ApoA-IV |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 45kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 4H5 |
| Immunogen | Purified recombinant fragment of ApoA-IV (aa21-396) expressed in E. Coli. |
| Specificity | ApoA-IV Monoclonal Antibody detects endogenous levels of ApoA-IV protein. |
| Gene Name | APOA4 |
| Protein Name | Apolipoprotein A-IV |
| Other Name | APOA4; / Apolipoprotein A-IV; / Apo-AIV; / ApoA-IV; / Apolipoprotein A4 |
| Species | Human |
| Gene ID | 337 |
| Uniprot | P06727, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P06728 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Synthesized primarily in the intestine and secreted in plasma. |
| Signaling_pathway | |
| Research Areas | >>Fat digestion and absorption; / >>Vitamin digestion and absorption; / >>Cholesterol metabolism; / >>Lipid and atherosclerosis |
| Function | Domain:Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.,Function:May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.,online information:The Singapore human mutation and polymorphism database,polymorphism:Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles.,similarity:Belongs to the apolipoprotein A1/A4/E family.,tissue specificity:Synthesized primarily in the intestine and secreted in plasma., |
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