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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/ApoO Monoclonal Antibody
SKU: WM0034 Categories: ,

ApoO Monoclonal Antibody

Ucallm_WM0034-50

Price range: $268.00 through $328.00

SKU: WM0034-50
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Product details

Background:
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009],

Specifications

Size50μL/100μL
TargetApoO
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)22kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number9C12
ImmunogenPurified recombinant fragment of ApoO expressed in E. Coli.
SpecificityApoO Monoclonal Antibody detects endogenous levels of ApoO protein.
Gene NameAPOO
Protein NameApolipoprotein O
Other NameAPOO; / FAM121B; / My025; / Apolipoprotein O; / Protein FAM121B
SpeciesHuman
Gene ID79135
UniprotQ9BUR5,
Species.1Mouse
Gene ID.168316
Uniprot.1Q9DCZ4
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMitochondrion inner membrane; Single-pass membrane protein . Secreted . Mitochondrion . Golgi apparatus membrane . Endoplasmic reticulum membrane . Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. .
Tissue ExpressionExpressed in all tissues examined. Up-regulated in diabetic heart.
Signaling_pathway
Research Areas
FunctionFunction:Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.,PTM:O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.,similarity:Belongs to the apolipoprotein O family.,tissue specificity:Expressed in all tissues examined. Up-regulated in diabetic heart.,
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