AQP5 Polyclonal Antibody
Ucallm_WP11098-50
Price range: $268.00 through $328.00
Product details
Background:
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | AQP5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 35kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AQP5. AA range:194-243 |
| Specificity | AQP5 Polyclonal Antibody detects endogenous levels of AQP5 protein. |
| Gene Name | AQP5 |
| Protein Name | Aquaporin-5 |
| Other Name | AQP5; / Aquaporin-5; / AQP-5 |
| Species | Human |
| Gene ID | 362 |
| Uniprot | P55064, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9WTY4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Apical cell membrane; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein . Cytoplasmic vesicle membrane; Multi-pass membrane protein . Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. . |
| Tissue Expression | Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level). |
| Signaling_pathway | |
| Research Areas | >>Salivary secretion |
| Function | Domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,Function:Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family., |
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