AR α2B Polyclonal Antibody
Ucallm_WP11101-50
Price range: $268.00 through $328.00
Product details
Background:
This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014],
Specifications
| Size | 50μL/100μL |
| Target | AR α2B |
| Reactivity | Human, Mouse, Rat |
| Applications | IF, ELISA |
| MW(Calculated) | 50kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications; |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2B. AA range:161-210 |
| Specificity | AR α2B Polyclonal Antibody detects endogenous levels of AR α2B protein. |
| Gene Name | ADRA2B |
| Protein Name | Alpha-2B adrenergic receptor |
| Other Name | ADRA2B; / ADRA2L1; / ADRA2RL1; / Alpha-2B adrenergic receptor; / Alpha-2 adrenergic receptor subtype C2; / Alpha-2B adrenoreceptor; / Alpha-2B adrenoceptor; / Alpha-2BAR |
| Species | Human |
| Gene ID | 151 |
| Uniprot | P18089, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P30545 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. . |
| Tissue Expression | Pooled, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | >>cGMP-PKG signaling pathway; / >>Neuroactive ligand-receptor interaction |
| Function | Function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.,polymorphism:A rare polymorphic framshift in position 451 produces a protein of 542 residues.,similarity:Belongs to the G-protein coupled receptor 1 family., |
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