Price range: $268.00 through $328.00
Background:
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009],
| Size | 50μL/100μL |
| Target | AR-β3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:100-300; ELISA 1:5000-20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADRB3. AA range:250-299 |
| Specificity | AR-β3 Polyclonal Antibody detects endogenous levels of AR-β3 protein. |
| Gene Name | ADRB3 |
| Protein Name | Beta-3 adrenergic receptor |
| Other Name | ADRB3; / ADRB3R; / B3AR; / Beta-3 adrenergic receptor; / Beta-3 adrenoreceptor; / Beta-3 adrenoceptor |
| Species | Human |
| Gene ID | 155 |
| Uniprot | P13945, |
| Species.1 | Mouse |
| Gene ID.1 | 11556 |
| Uniprot.1 | P25962, |
| Species.2 | Rat |
| Gene ID.2 | 25645 |
| Uniprot.2 | P26255 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Expressed mainly in adipose tissues. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | >>Calcium signaling pathway; / >>cGMP-PKG signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Thermogenesis; / >>Regulation of lipolysis in adipocytes; / >>Renin secretion; / >>Salivary secretion; / >>Chemical carcinogenesis - receptor activation |
| Function | Function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.,polymorphism:The variant Arg-64 seems to be associated with weight gain (obesity) and to is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed mainly in adipose tissues., |
