Product details
Background:
RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004],
- Please choose product options by visiting MFSD8 Polyclonal Antibody.
ARHGAP17 Polyclonal Antibody
Ucallm_WP11118-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ARHGAP17 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 100kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RHG17. AA range:331-380 |
| Specificity | ARHGAP17 Polyclonal Antibody detects endogenous levels of ARHGAP17 protein. |
| Gene Name | ARHGAP17 |
| Protein Name | Rho GTPase-activating protein 17 |
| Other Name | ARHGAP17; / RICH1; / MSTP066; / MSTP110; / Rho GTPase-activating protein 17; / Rho-type GTPase-activating protein 17; / RhoGAP interacting with CIP4 homologs protein 1; / RICH-1 |
| Species | Human |
| Gene ID | 55114 |
| Uniprot | Q68EM7, |
| Species.1 | Mouse |
| Gene ID.1 | 70497 |
| Uniprot.1 | Q3UIA2, |
| Species.2 | Rat |
| Gene ID.2 | 63994 |
| Uniprot.2 | Q99N37 |
| Cellular Localization | Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Associates with membranes and concentrates at sites of cell-cell contact. |
| Tissue Expression | Ubiquitously expressed. Expressed at higher level in heart and placenta. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction |
| Research Areas | >>Tight junction |
| Function | Domain:The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions.,Function:Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1.,similarity:Contains 1 BAR domain.,similarity:Contains 1 Rho-GAP domain.,subcellular location:Associates with membranes and concentrates at sites of cell-cell contact.,subunit:Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with SLC9A3R1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.,tissue specificity:Ubiquitously expressed. Expressed at higher level in heart and placenta., |
Please login to post questions
Related products
