Name: ARY2 rabbit pAb
SKU: WP17568
Price: 268 USD
Availability: InStock

ARY2 rabbit pAb

Ucallm_WP17568-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP17568-100

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	ARY2
Reactivity	Human, Mouse, Rat
Applications	WB
MW(Calculated)	32kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human ARY2 AA range: 80-130
Specificity	This antibody detects endogenous levels of ARY2 at Human/Mouse/Rat
Gene Name	NAT2 AAC2
Protein Name	ARY2
Other Name
Species	Human
Gene ID	10
Uniprot	P11245,
Species.1	Mouse
Gene ID.1	17961
Uniprot.1	P50295,
Species.2	Rat
Gene ID.2	116632
Uniprot.2	P50298
Cellular Localization	Cytoplasm.
Tissue Expression
Signaling_pathway
Research Areas	>>Caffeine metabolism; / >>Drug metabolism - other enzymes; / >>Metabolic pathways; / >>Chemical carcinogenesis - DNA adducts
Function	Catalytic activity:Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.,Disease:Genetic variations in NAT2 determine N-acetylation polymorphism by a low or high NAT activity in the liver [MIM:243400]. It has been implicated in the action and toxicity of amine-containing drugs, and in the susceptibility to bladder cancer and systemic lupus erythematosus. This isozyme is responsible for this polymorphism.,Function:Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.,online information:NAT alleles,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the arylamine N-acetyltransferase family.,