Price range: $268.00 through $328.00
Background:
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | Arylsulfatase K |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 62kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ARSK. AA range:481-530 |
| Specificity | Arylsulfatase K Polyclonal Antibody detects endogenous levels of Arylsulfatase K protein. |
| Gene Name | ARSK |
| Protein Name | Arylsulfatase K |
| Other Name | ARSK; / TSULF; / Arylsulfatase K; / ASK; / Telethon sulfatase |
| Species | Human |
| Gene ID | 153642 |
| Uniprot | Q6UWY0, |
| Species.1 | Mouse |
| Gene ID.1 | 77041 |
| Uniprot.1 | Q9D2L1, |
| Species.2 | Rat |
| Gene ID.2 | 365619 |
| Uniprot.2 | Q32KJ2 |
| Cellular Localization | Secreted . Lysosome . |
| Tissue Expression | Expressed at high levels in the placenta and pancreas (PubMed:23986440). Expressed at intermediate levels in the lung, brain, heart, liver and kidney and at low levels in the muscle (PubMed:23986440). |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:Binds 1 calcium ion per subunit.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family., |
