ASCL1 Polyclonal Antibody
Ucallm_WP15845-50
Price range: $268.00 through $328.00
Product details
Background:
achaete-scute family bHLH transcription factor 1(ASCL1) Homo sapiens This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | ASCL1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic peptide from human protein at AA range: 190-236 |
| Specificity | The antibody detects endogenous ASCL1 |
| Gene Name | ASCL1 ASH1 BHLHA46 HASH1 |
| Protein Name | Achaete-scute homolog 1 |
| Other Name | ASCL1; / ASH1; / BHLHA46; / HASH1; / Achaete-scute homolog 1; / ASH-1; / hASH1; / Class A basic helix-loop-helix protein 46; / bHLHa46 |
| Species | Human |
| Gene ID | 429 |
| Uniprot | P50553, |
| Species.1 | Mouse |
| Gene ID.1 | 17172 |
| Uniprot.1 | Q02067, |
| Species.2 | Rat |
| Gene ID.2 | 64186 |
| Uniprot.2 | P19359 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Lung,Thyroid carcinoma, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Activates transcription by binding to the E box (5'-CANNTG-3').,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3., |
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