Name: AT1 Polyclonal Antibody
SKU: WP11170
Price: 268 USD
Availability: InStock

Product details

Background:

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012],

Specifications

Target	AGTR1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	41kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human AGTR1. AA range:101-150
Sequence
Specificity	AT1 Polyclonal Antibody detects endogenous levels of AT1 protein.
Gene Name	AGTR1 AGTR1A AGTR1B AT2R1 AT2R1B
Protein Name	Type-1 angiotensin II receptor
Other Name	AGTR1; / AGTR1A; / AGTR1B; / AT2R1; / AT2R1B; / Type-1 angiotensin II receptor; / AT1AR; / AT1BR; / Angiotensin II type-1 receptor; / AT1
Species	Human
Gene ID-1	185
Uniprot	P30556,
Species.1
Gene ID-2
Uniprot.1
Species.2	Rat
Gene ID-3	24180
Uniprot.2	P25095
Organism-4
Gene ID-4
SwissProt-4
Background	Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012],
Cellular Localization	Cell membrane; Multi-pass membrane protein .
Tissue Expression	Liver, lung, adrenal and adrenocortical adenomas.
Signaling_pathway	Organismal Systems >> Endocrine system >> Renin-angiotensin system;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Research Areas	>>Calcium signaling pathway; / >>cGMP-PKG signaling pathway; / >>Phospholipase D signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Adrenergic signaling in cardiomyocytes; / >>Vascular smooth muscle contraction; / >>Apelin signaling pathway; / >>Renin-angiotensin system; / >>Renin secretion; / >>Aldosterone synthesis and secretion; / >>Cortisol synthesis and secretion; / >>AGE-RAGE signaling pathway in diabetic complications; / >>Cushing syndrome; / >>Coronavirus disease - COVID-19; / >>Pathways in cancer; / >>Diabetic cardiomyopathy
Function	Disease:Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).,Function:Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,online information:Angiotensin receptor entry,online information:The Singapore human mutation and polymorphism database,PTM:C-terminal Ser or Thr residues may be phosphorylated.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Liver, lung, adrenal and adrenocortical adenomas.,
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AT1 Polyclonal Antibody

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AT1 Polyclonal Antibody

Product details

Specifications

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