Product details
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ATF7IP rabbit pAb
Ucallm_WP7722-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ATF7IP |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 140kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ATF7IP |
| Specificity | This antibody detects endogenous levels of ATF7IP at Human, Mouse |
| Gene Name | ATF7IP MCAF MCAF1 |
| Protein Name | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) |
| Other Name | |
| Species | Human |
| Gene ID | 55729 |
| Uniprot | Q6VMQ6, |
| Species.1 | Mouse |
| Gene ID.1 | 54343 |
| Uniprot.1 | Q7TT18 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing . Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 . Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) . Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells . |
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