ATP-Citrate Lyase [C-term] mouse mAb
Ucallm_WM0593-50
Price range: $268.00 through $328.00
Product details
Background:
ATP citrate lyase(ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440, 000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],
Specifications
| Size | 50μL/100μL |
| Target | ATP-citrate synthase |
| Reactivity | Human, Mouse, Monkey |
| Applications | WB, ICC, FC |
| MW(Calculated) | |
| MW(Observed) | 120kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; ICC 1:150; Flow Cyt 1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 7E4 |
| Immunogen | Purified recombinant human ATP-Citrate Lyase protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of ATP-Citrate Lyase and does not cross-react with related proteins. |
| Gene Name | acly |
| Protein Name | |
| Other Name | ACL; / Acly; / ACLY_HUMAN; / ATP citrate; / pro-S; / lyase; / ATP citrate lyase; / ATP citrate synthase; / ATP-citrate; / pro-S-; / -lyase; / ATP-citrate synthase; / ATPcitrate synthase; / ATPCL; / Citrate cleavage enzyme; / CLATP; / OTTHUMP00000164773. |
| Species | Human |
| Gene ID | 47 |
| Uniprot | P53396, |
| Species.1 | Mouse |
| Gene ID.1 | 104112 |
| Uniprot.1 | Q91V92 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytosol . |
| Tissue Expression | Brain,Epithelium,Hippocampus,Liver,Lymph,Platelet, |
| Signaling_pathway | |
| Research Areas | >>Citrate cycle (TCA cycle); / >>Metabolic pathways |
| Function | Catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.,Function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.,subunit:Homotetramer., |
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