Price range: $268.00 through $328.00
Background:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
| Size | 50μL/100μL |
| Target | ATP1AL1 |
| Reactivity | Human, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 115kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from ATP1AL1 . at AA range: 380-460 |
| Specificity | ATP1AL1 Polyclonal Antibody detects endogenous levels of ATP1AL1 protein. |
| Gene Name | ATP12A |
| Protein Name | Potassium-transporting ATPase alpha chain 2 |
| Other Name | ATP12A; / ATP1AL1; / Potassium-transporting ATPase alpha chain 2; / Non-gastric H; / +; / /K; / +; / ATPase subunit alpha; / Proton pump |
| Species | Human |
| Gene ID | 479 |
| Uniprot | P54707, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z1W8, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P54708 |
| Cellular Localization | Apical cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed in airway epithelial cells (at protein level) (PubMed:29391451). Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level). |
| Signaling_pathway | |
| Research Areas | >>Oxidative phosphorylation; / >>Metabolic pathways |
| Function | Catalytic activity:ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).,Function:Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.,subunit:Composed of two subunits: alpha (catalytic) and beta.,tissue specificity:Found in skin and kidney., |
