Price range: $268.00 through $328.00
Background:
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | AVPR1A |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AVPR1A. at AA range: 11-60 |
| Specificity | AVPR1A Polyclonal Antibody detects endogenous levels of AVPR1A |
| Gene Name | AVPR1A |
| Protein Name | AVPR1A |
| Other Name | Vasopressin V1a receptor; / V1aR; / AVPR V1a; / Antidiuretic hormone receptor 1a; / Vascular/hepatic-type arginine vasopressin receptor |
| Species | Human |
| Gene ID | 552 |
| Uniprot | P37288, |
| Species.1 | Mouse |
| Gene ID.1 | 54140 |
| Uniprot.1 | Q62463 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Liver,Lung, |
| Signaling_pathway | Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway |
| Research Areas | >>Calcium signaling pathway; / >>Phospholipase D signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Vascular smooth muscle contraction |
| Function | Function:Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.,miscellaneous:Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.,similarity:Belongs to the G-protein coupled receptor 1 family., |
