Axl Monoclonal Antibody
Ucallm_WM0045-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
Specifications
| Size | 50μL/100μL |
| Target | Axl |
| Reactivity | Human |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 130kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 1D10 |
| Immunogen | Purified recombinant extracellular fragment of human Axl fused with hIgGFc tag expressed in HEK293 cell line. |
| Specificity | Axl Monoclonal Antibody detects endogenous levels of Axl protein. |
| Gene Name | AXL UFO |
| Protein Name | Tyrosine-protein kinase receptor UFO |
| Other Name | AXL; / UFO; / Tyrosine-protein kinase receptor UFO; / AXL oncogene |
| Species | Human |
| Gene ID | 558 |
| Uniprot | P30530, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q00993 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. |
| Signaling_pathway | |
| Research Areas | >>EGFR tyrosine kinase inhibitor resistance |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia.,Function:May function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Heterodimer and heterotetramer with GAS6.,tissue specificity:Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue., |
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