B4GN2 Polyclonal Antibody
Ucallm_WP0926-50
Price range: $268.00 through $328.00
Product details
Background:
beta-1, 4-N-acetyl-galactosaminyltransferase 2(B4GALNT2) Homo sapiens B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1, 4 linkage to a subterminal galactose residue substituted with an alpha-2, 3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008],
Specifications
| Size | 50μL/100μL |
| Target | B4GN2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 62kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | B4GN2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | B4GALNT2 GALGT2 |
| Protein Name | Beta-1,4 N-acetylgalactosaminyltransferase 2 (Sd(a) beta-1,4-GalNAc transferase) (UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase) |
| Other Name | |
| Species | Human |
| Gene ID | 124872 |
| Uniprot | Q8NHY0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q09199 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus membrane; Single-pass type II membrane protein . |
| Tissue Expression | Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.,online information:Beta-1,4 N-acetylgalactosaminyltransferase 2,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family.,tissue specificity:Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum., |
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