B4GT6 Polyclonal Antibody
Ucallm_WP0928-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is one of seven beta-1, 4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1, 4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Ju
Specifications
| Size | 50μL/100μL |
| Target | B4GT6 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | B4GT6 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | B4GALT6 |
| Protein Name | Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6) [Includes: Glucosylceramide beta-1,4-galactosyltransferase (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase)] |
| Other Name | |
| Species | Human |
| Gene ID | 9331 |
| Uniprot | Q9UBX8, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9WVK5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | O88419 |
| Cellular Localization | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Trans cisternae of Golgi stack. . |
| Tissue Expression | High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells. |
| Signaling_pathway | |
| Research Areas | >>Sphingolipid metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:UDP-galactose + glucosylceramide = UDP + lactosylceramide.,cofactor:Manganese or magnesium or calcium.,enzyme regulation:Inhibited by EDTA.,Function:Required for the biosynthesis of glycosphingolipids.,online information:Beta-1,4-galactosyltransferase 6,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 7 family.,subcellular location:Trans cisternae of Golgi stack.,tissue specificity:High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells., |
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