Name: Bak Polyclonal Antibody
SKU: WP11246
Price: 268 USD
Availability: InStock

Product details

Background:

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Bak
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	25kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:100-300; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human Bak. AA range:1-50
Specificity	Bak Polyclonal Antibody detects endogenous levels of Bak protein.
Gene Name	BAK1
Protein Name	Bcl-2 homologous antagonist/killer
Other Name	BAK1; / BAK; / BCL2L7; / CDN1; / Bcl-2 homologous antagonist/killer; / Apoptosis regulator BAK; / Bcl-2-like protein 7; / Bcl2-L-7
Species	Human
Gene ID	578
Uniprot	Q16611,
Species.1	Mouse
Gene ID.1
Uniprot.1	O08734
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Mitochondrion outer membrane; Single-pass membrane protein .
Tissue Expression	Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Apoptosis;Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: specific types >> Colorectal cancer;Human Diseases >> Cancer: specific types >> Pancreatic cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Glioma;Human Diseases >> Cancer: specific types >> Thyroid cancer;Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia;Human Diseases >> Cancer: specific types >> Basal cell carcinoma;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Endometrial cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Human Diseases >> Cancer: specific types >> Small cell lung cancer;Human Diseases >> Cancer: specific types >> Non-small cell lung cancer;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Research Areas	>>Platinum drug resistance; / >>Protein processing in endoplasmic reticulum; / >>Apoptosis; / >>Apoptosis - multiple species; / >>Pathways of neurodegeneration - multiple diseases; / >>Pathogenic Escherichia coli infection; / >>Salmonella infection; / >>Hepatitis C; / >>Measles; / >>Human cytomegalovirus infection; / >>Influenza A; / >>Human papillomavirus infection; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Herpes simplex virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Viral carcinogenesis; / >>MicroRNAs in cancer; / >>Colorectal cancer; / >>Pancreatic cancer; / >>Endometrial cancer; / >>Glioma; / >>Thyroid cancer; / >>Basal cell carcinoma; / >>Melanoma; / >>Chronic myeloid leukemia; / >>Small cell lung cancer; / >>Non-small cell lung cancer; / >>Breast cancer; / >>Hepatocellular carcinoma; / >>Gastric cancer
Function	Caution:Could be the product of a pseudogene.,Domain:Intact BH3 domain is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family.,Domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,Function:In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a repressor Bcl-2 or its adenovirus homolog E1B 19k protein.,Function:In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a. repressor BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.,similarity:Belongs to the Bcl-2 family.,subunit:Forms heterodimers with Bcl-2, E1B 19k protein, and Bcl-X(L).,subunit:Interacts with BCL2A1 (By similarity). Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L).,tissue specificity:Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.,

Please login to post questions

Bak Polyclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

Bak Polyclonal Antibody

Product details

Specifications

Related products

U-Blot® GAPDH Rabbit mAb

U-Blot® Smad2 (Phospho Ser250) Rabbit mAb

U-Blot® NQO1 Rabbit mAb

U-Blot® CDC37 (Phospho Ser13) Rabbit mAb

U-Blot® VEGF Receptor 1 Rabbit mAb

U-Blot® PMS2 Rabbit mAb

Customer Reviews

Menu