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Bax mouse mAb
Ucallm_WM0693-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.
Specifications
| Specification | 50μL;100μL |
| Target | Bax |
| Reactivity | Human, Monkey |
| Applications | WB, IF |
| MW(Calculated) | |
| MW(Observed) | 20kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate | |
| Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000;IF/ICC1:200-400 |
| Composition | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification Process | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Puity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Purified recombinant human Bax protein fragments expressed in E.coli |
| Sequence | |
| Specificity | This antibody detects endogenous levels of Bax and does not cross-react with related proteins. |
| Gene Name | bax |
| Protein Name | |
| Alias | Apoptosis regulator BAX;Apoptosis regulator BAX cytoplasmic isoform beta;Apoptosis regulator BAX membrane isoform alpha;BAX;Bax isoform psi;BAX protein cytoplasmic isoform delta;Bax protein cytoplasmic isoform delta.;Bax protein cytoplasmic isoform gamma;Bax zeta;Bax-protein;BAX_HUMAN;BAXA;Bcl-2-like protein 4;BCL2 associated X protein;BCL2 associated X protein omega;BCL2 associated X protein transcript variant delta2;Bcl2-L-4;BCL2L4;membrane isoform alpha. |
| Organism-1 | Human |
| Gene ID-1 | 581 |
| SwissProt-1 | Q07812 |
| Organism-2 | Mouse |
| Gene ID-2 | |
| SwissProt-2 | Q07813 |
| Organism-3 | |
| Gene ID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization | [Isoform Alpha]: Mitochondrion outer membrane ; Single-pass membrane protein . Cytoplasm . Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. Upon Sendai virus infection, recruited to the mitochondrion through interaction with IRF3 (PubMed:25609812). .; [Isoform Beta]: Cytoplasm.; [Isoform Gamma]: Cytoplasm.; [Isoform Delta]: Cytoplasm . |
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