BC11B Polyclonal Antibody
Ucallm_WP2117-50
Price range: $268.00 through $328.00
Product details
Background:
B-cell CLL/lymphoma 11B(BCL11B) Homo sapiens This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013],
Specifications
| Size | 50μL/100μL |
| Target | Ctip2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 98kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 570-650 |
| Specificity | BC11B Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | BCL11B CTIP2 RIT1 |
| Protein Name | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) |
| Other Name | |
| Species | Human |
| Gene ID | 64919 |
| Uniprot | Q9C0K0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99PV8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer |
| Research Areas | >>Transcriptional misregulation in cancer |
| Function | Function:Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with TFCOUP1, SIRT1, ARP1 and EAR2.,tissue specificity:Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma., |
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