Bcl-10 Monoclonal Antibody
Ucallm_WM0047-50
Price range: $268.00 through $328.00
Product details
Background:
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Specifications
| Size | 50μL/100μL |
| Target | Bcl-10 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, FC, ELISA |
| MW(Calculated) | 26kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 6G1 |
| Immunogen | Purified recombinant fragment of human Bcl-10 expressed in E. Coli. |
| Specificity | Bcl-10 Monoclonal Antibody detects endogenous levels of Bcl-10 protein. |
| Gene Name | BCL10 |
| Protein Name | B-cell lymphoma/leukemia 10 |
| Other Name | BCL10; / CIPER; / CLAP; / B-cell lymphoma/leukemia 10; / B-cell CLL/lymphoma 10; / Bcl-10; / CARD-containing molecule enhancing NF-kappa-B; / CARD-like apoptotic protein; / hCLAP; / CED-3/ICH-1 prodomain homologous E10-like regulator; / CIPER; / Cellular homolog |
| Species | Human |
| Gene ID | 8915 |
| Uniprot | O95999, |
| Species.1 | Mouse |
| Gene ID.1 | 12042 |
| Uniprot.1 | Q9Z0H7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, perinuclear region . Membrane raft . Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts. . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway |
| Research Areas | >>NF-kappa B signaling pathway; / >>C-type lectin receptor signaling pathway; / >>T cell receptor signaling pathway; / >>B cell receptor signaling pathway; / >>Shigellosis; / >>Tuberculosis |
| Function | Disease:A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1; 14)(p22; q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.,Disease:Defects in BCL10 are involved in various types of cancer.,Function:Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.,PTM:Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2.,similarity:Contains 1 CARD domain.,subcellular location:Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells.,subunit:Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2.,tissue specificity:Ubiquitous., |
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