Product details
Background:
disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1., disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF., disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions., function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis., induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan., PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway., similarity:Contains 1 BTB (POZ) domain., similarity:Contains 6 C2H2-type zinc fingers., subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9., tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.,
