Bcl-6 Polyclonal Antibody
Ucallm_WP15375-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015],
Specifications
| Size | 50μL/100μL |
| Target | Bcl-6 |
| Reactivity | Human, Mouse, Rat |
| Applications | IF, WB, IHC, ELISA |
| MW(Calculated) | |
| MW(Observed) | 78kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IF 1:50-200; WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; Not yet tested in other applications; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human BCL6. AA range:271-320 |
| Specificity | Bcl-6 Polyclonal Antibody detects endogenous levels of Bcl-6 protein. |
| Gene Name | BCL6 |
| Protein Name | B-cell lymphoma 6 protein |
| Other Name | BCL6; / BCL5; / LAZ3; / ZBTB27; / ZNF51; / B-cell lymphoma 6 protein; / BCL-6; / B-cell lymphoma 5 protein; / BCL-5; / Protein LAZ-3; / Zinc finger and BTB domain-containing protein 27; / Zinc finger protein 51 |
| Species | Human |
| Gene ID | 604 |
| Uniprot | P41182, |
| Species.1 | Mouse |
| Gene ID.1 | 12053 |
| Uniprot.1 | P41183 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Expressed in germinal center T- and B-cells and in primary immature dendritic cells. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway |
| Research Areas | >>FoxO signaling pathway; / >>Transcriptional misregulation in cancer; / >>Chemical carcinogenesis - receptor activation |
| Function | Disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3; 11)(q27; q23) with POU2AF1/OBF1.,Disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3; 4)(q27; p11) with ARHH/TTF.,Disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3; 14)(q27; q32); translocation t(3; 22)(q27; q11) with immunoglobulin gene regions.,Function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.,induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan.,PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.,tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells., |
Please login to post questions
Related products
