BCL3 Polyclonal Antibody
Ucallm_WP0489-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | BCL3 |
| Reactivity | Human, Rat, Mouse, Goat |
| Applications | IHC, IF, WB |
| MW(Calculated) | |
| MW(Observed) | 49kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:50-200; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 340-420 |
| Specificity | BCL3 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | BCL3 BCL4 D19S37 |
| Protein Name | B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) |
| Other Name | |
| Species | Human |
| Gene ID | 602 |
| Uniprot | P20749, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z2F6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Cytoplasm . Cytoplasm, perinuclear region . Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. . |
| Tissue Expression | Leukemia,Lung, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> TNF signaling pathway |
| Research Areas | >>C-type lectin receptor signaling pathway; / >>TNF signaling pathway |
| Function | Disease:A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14; 19)(q32; q13.1) with immunoglobulin gene regions.,Function:Could be a transcriptional activating factor. Functions as a form of I-kappa-B specific for NF-kappa-B p50 subunit inhibiting its translocation to the nucleus.,PTM:Activated by phosphorylation.,similarity:Contains 7 ANK repeats.,subunit:Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2 and COPS5., |
Please login to post questions
Related products
