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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/Beclin-1 Monoclonal Antibody
SKU: WM0049 Categories: ,

Beclin-1 Monoclonal Antibody

Ucallm_WM0049-50

Price range: $268.00 through $328.00

SKU: WM0049-50
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Product details

Background:
beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

Specifications

Size50μL/100μL
TargetBeclin 1
ReactivityHuman
ApplicationsWB, IHC, IF, FC, ELISA
MW(Calculated)52kD
MW(Observed)
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationAffinity purification
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number2D11
ImmunogenPurified recombinant fragment of human Beclin-1 expressed in E. Coli.
SpecificityBeclin-1 Monoclonal Antibody detects endogenous levels of Beclin-1 protein.
Gene NameBECN1
Protein NameBeclin-1
Other NameBECN1; / GT197; / Beclin-1; / Coiled-coil myosin-like BCL2-interacting protein; / Protein GT197
SpeciesHuman
Gene ID8678
UniprotQ14457,
Species.1Mouse
Gene ID.1
Uniprot.1O88597
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm . Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein . Endosome membrane; Peripheral membrane protein . Endoplasmic reticulum membrane; Peripheral membrane protein . Mitochondrion membrane; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .; [Beclin-1-C 35 kDa]: Mitochondrion . Nucleus . Cytoplasm .; [Beclin-1-C 37 kDa]: Mitochondrion .
Tissue ExpressionUbiquitous.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Research Areas>>Autophagy - other; / >>Mitophagy - animal; / >>Autophagy - animal; / >>Apoptosis - multiple species; / >>Apelin signaling pathway; / >>Alzheimer disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Spinocerebellar ataxia; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis; / >>Kaposi sarcoma-associated herpesvirus infection
FunctionFunction:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous.,
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