Price range: $268.00 through $328.00
Background:
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. [provided by RefSeq, Oct 2016],
| Size | 50μL/100μL |
| Target | BHE22 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 42kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human BHE22 AA range: 243-293 |
| Specificity | This antibody detects endogenous levels of BHE22 at Human/Mouse |
| Gene Name | BHLHE22 BHLHB5 TNRC20 |
| Protein Name | BHE22 |
| Other Name | |
| Species | Human |
| Gene ID | 27319 |
| Uniprot | Q8NFJ8, |
| Species.1 | Mouse |
| Gene ID.1 | 59058 |
| Uniprot.1 | Q8C6A8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Brain-specific, with the highest expression in the cerebellum. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,tissue specificity:Brain-specific, with the highest expression in the cerebellum., |
