Name: BID (Cleaved-Arg71) rabbit pAb
SKU: WP0103
Price: 268 USD
Availability: InStock

Product details

Background:

domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family., function:The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products., subcellular location:A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively., subcellular location:Associated with the mitochondrial membrane., subcellular location:Translocates to mitochondria as an integral membrane protein., subcellular location:When uncleaved, it is predominantly cytoplasmic., subunit:Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2., tissue specificity:Isoforms 2 and 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).,

Specifications

Size	50μL/100μL
Target	BID
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	8kD,22kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human BID (Cleaved-Arg71)
Specificity	This antibody detects endogenous levels of Human,Mouse BID (Cleaved-Arg71, protein was cleaved amino acid sequence between 71-72)
Gene Name	BID
Protein Name	BID (Cleaved-Arg71)
Other Name	BH3-interacting domain death agonist; / p22 BID; / BID; / [Cleaved into: BH3-interacting domain death agonist p15; / p15 BID; / BH3-interacting domain death agonist p13; / p13 BID; / BH3-interacting domain death agonist p11; / p11 BID; / ]
Species	Human
Gene ID	637
Uniprot	P55957,
Species.1	Mouse
Gene ID.1	12122
Uniprot.1	P70444
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Mitochondrion membrane . Mitochondrion outer membrane . When uncleaved, it is predominantly cytoplasmic. .; [BH3-interacting domain death agonist p15]: Mitochondrion membrane . Translocates to mitochondria as an integral membrane protein. .; [BH3-interacting domain death agonist p13]: Mitochondrion membrane . Associated with the mitochondrial membrane. .; [Isoform 1]: Cytoplasm .; [Isoform 3]: Cytoplasm .; [Isoform 2]: Mitochondrion membrane . A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. .
Tissue Expression	[Isoform 2]: Expressed in spleen, pancreas and placenta (at protein level).; [Isoform 3]: Expressed in lung, pancreas and spleen (at protein level).; [Isoform 4]: Expressed in lung and pancreas (at protein level).
Signaling_pathway	Cellular Processes >> Cell growth and death >> Apoptosis;Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Cellular Processes >> Cell growth and death >> Necroptosis;Cellular Processes >> Cell growth and death >> p53 signaling pathway;Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway
Research Areas	>>Platinum drug resistance; / >>Sphingolipid signaling pathway; / >>p53 signaling pathway; / >>Apoptosis; / >>Apoptosis - multiple species; / >>Necroptosis; / >>Natural killer cell mediated cytotoxicity; / >>Non-alcoholic fatty liver disease; / >>Alzheimer disease; / >>Amyotrophic lateral sclerosis; / >>Pathways of neurodegeneration - multiple diseases; / >>Tuberculosis; / >>Hepatitis C; / >>Hepatitis B; / >>Measles; / >>Human cytomegalovirus infection; / >>Influenza A; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Herpes simplex virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>Pathways in cancer; / >>Viral myocarditis; / >>Lipid and atherosclerosis
Function	release of cytochrome c from mitochondria, protein targeting, protein targeting to mitochondrion, mitochondrial transport, intracellular protein transport, apoptosis, induction of apoptosis, mitochondrion organization, mitochondrial membrane organization, protein localization, cell death, induction of apoptosis by extracellular signals, activation of pro-apoptotic gene products, apoptotic mitochondrial changes, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, protein transport, membrane organization, death,protein import, protein localization in organelle, cellular protein localization, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, establishment of protein localization, regulation of mitochondrial membrane permeability, intracellular transport, neuron apoptosis,protein localization in mitochondrion, cellular macromolecule localization,

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BID (Cleaved-Arg71) rabbit pAb

Product details

Specifications

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BID (Cleaved-Arg71) rabbit pAb

Product details

Specifications

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