BinCARD Polyclonal Antibody
Ucallm_WP11278-50
Price range: $268.00 through $328.00
Product details
Background:
function:Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner., PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 CARD domain., subcellular location:Co-expression with BCL10 induced translocation from nucleus to cytosol., subunit:Associates with BCL10 by CARD-CARD interaction., tissue specificity:Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.,
Specifications
| Size | 50μL/100μL |
| Target | BinCARD |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 26kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human C9orf89. AA range:21-70 |
| Specificity | BinCARD Polyclonal Antibody detects endogenous levels of BinCARD protein. |
| Gene Name | C9orf89 |
| Protein Name | Bcl10-interacting CARD protein |
| Other Name | C9orf89; / Bcl10-interacting CARD protein; / BinCARD |
| Species | Human |
| Gene ID | 84270 |
| Uniprot | Q96LW7, |
| Species.1 | Mouse |
| Gene ID.1 | 68480 |
| Uniprot.1 | Q9D1I2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Nucleus . Coexpression with BCL10 induced translocation from nucleus to cytosol.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein . Mitochondrion membrane; Single-pass membrane protein . |
| Tissue Expression | Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 CARD domain.,subcellular location:Co-expression with BCL10 induced translocation from nucleus to cytosol.,subunit:Associates with BCL10 by CARD-CARD interaction.,tissue specificity:Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain., |
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