Price range: $268.00 through $328.00
Background:
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | Blimp-1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | 92kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 9A8 |
| Immunogen | Purified recombinant fragment of human Blimp-1 expressed in E. Coli. |
| Specificity | Blimp-1 Monoclonal Antibody detects endogenous levels of Blimp-1 protein. |
| Gene Name | PRDM1 |
| Protein Name | PR domain zinc finger protein 1 |
| Other Name | PRDM1; / BLIMP1; / PR domain zinc finger protein 1; / BLIMP-1; / Beta-interferon gene positive regulatory domain I-binding factor; / PR domain-containing protein 1; / Positive regulatory domain I-binding factor 1; / PRDI-BF1; / PRDI-binding factor 1 |
| Species | Human |
| Gene ID | 639 |
| Uniprot | O75626, |
| Species.1 | Mouse |
| Gene ID.1 | 12142 |
| Uniprot.1 | Q60636 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . |
| Tissue Expression | PCR rescued clones,Stomach, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.,similarity:Contains 1 SET domain.,similarity:Contains 4 C2H2-type zinc fingers.,subunit:Interacts with PRMT5., |
