Name: BMP-7 Polyclonal Antibody
SKU: WP11288
Price: 268 USD
Availability: InStock

BMP-7 Polyclonal Antibody

Ucallm_WP11288-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP11288-100

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Product details

Background:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016],

Specifications

Size	50μL/100μL
Target	BMP-7
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	55kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human BMP-7. AA range:124-173
Specificity	BMP-7 Polyclonal Antibody detects endogenous levels of BMP-7 protein.
Gene Name	BMP7
Protein Name	Bone morphogenetic protein 7
Other Name	BMP7; / OP1; / Bone morphogenetic protein 7; / BMP-7; / Osteogenic protein 1; / OP-1; / Eptotermin alfa
Species	Human
Gene ID	655
Uniprot	P18075,
Species.1	Mouse
Gene ID.1	12162
Uniprot.1	P23359
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted.
Tissue Expression	Expressed in the kidney and bladder. Lower levels seen in the brain.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>TGF-beta signaling pathway; / >>Axon guidance; / >>Hippo signaling pathway
Function	Function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 7 entry,pharmaceutical:Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.,PTM:Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.,tissue specificity:Expressed in the kidneys and bladder. Lower levels seen in the brain.,

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BMP-7 Polyclonal Antibody

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BMP-7 Polyclonal Antibody

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