BRCAA1 Polyclonal Antibody
Ucallm_WP11302-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | BRCAA1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 148kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BRCAA1. AA range:761-810 |
| Specificity | BRCAA1 Polyclonal Antibody detects endogenous levels of BRCAA1 protein. |
| Gene Name | ARID4B |
| Protein Name | AT-rich interactive domain-containing protein 4B |
| Other Name | ARID4B; / BRCAA1; / RBBP1L1; / RBP1L1; / SAP180; / AT-rich interactive domain-containing protein 4B; / ARID domain-containing protein 4B; / 180 kDa Sin3-associated polypeptide; / Sin3-associated polypeptide p180; / Breast cancer-associated antigen BRCAA1; / Hi |
| Species | Human |
| Gene ID | 51742 |
| Uniprot | Q4LE39, |
| Species.1 | Mouse |
| Gene ID.1 | 94246 |
| Uniprot.1 | A2CG63, |
| Species.2 | Rat |
| Gene ID.2 | 84481 |
| Uniprot.2 | Q9JKB5 |
| Cellular Localization | Nucleus . Cytoplasm . Cytoplasmic in breast cancer cells. . |
| Tissue Expression | Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.,Domain:The C-terminus mediates interaction with mSin3A corepressor complex.,Domain:The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,Function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Contains 1 ARID domain.,subcellular location:Cytoplasmic in breast cancer cells.,subunit:Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.,tissue specificity:Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary., |
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