Price range: $268.00 through $328.00
Background:
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009],
| Size | 50μL/100μL |
| Target | Brn-3 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 35kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human POU4F3. AA range:231-280 |
| Specificity | Brn-3 Polyclonal Antibody detects endogenous levels of Brn-3 protein. |
| Gene Name | POU4F3 |
| Protein Name | POU domain class 4 transcription factor 3 |
| Other Name | POU4F3; / BRN3C; / POU domain; / class 4, transcription factor 3; / Brain-specific homeobox/POU domain protein 3C; / Brain-3C; / Brn-3C |
| Species | Human |
| Gene ID | 5459 |
| Uniprot | Q15319, |
| Species.1 | Mouse |
| Gene ID.1 | 18998 |
| Uniprot.1 | Q63955 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Preferentially localized in the nucleus. . |
| Tissue Expression | Brain. Seems to be specific to the retina. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in POU4F3 are the cause of non-syndromic sensorineural deafness autosomal dominant type 15 (DFNA15) [MIM:602459]. DFNA15 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,Function:May play a role in determining or maintaining the identities of a small subset of visual system neurons.,online information:Gene page,similarity:Belongs to the POU transcription factor family. Class-4 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,tissue specificity:Brain. Seems to be specific to the retina., |
