Product details
Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-205 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39., function:Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 UBA domain., subcellular location:Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage., tissue specificity:Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.,
