Price range: $268.00 through $328.00
Background:
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | BTBD1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 53kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human BTBD1 AA range: 115-165 |
| Specificity | This antibody detects endogenous levels of BTBD1 at Human/Mouse |
| Gene Name | BTBD1 C15orf1 NS5ATP8 |
| Protein Name | BTBD1 |
| Other Name | |
| Species | Human |
| Gene ID | 53339 |
| Uniprot | Q9H0C5, |
| Species.1 | Mouse |
| Gene ID.1 | 83962 |
| Uniprot.1 | P58544 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Localizes to punctate or elongated cytoplasmic bodies. . |
| Tissue Expression | Ubiquitous; highest levels in testes, heart and skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Function:Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BTB (POZ) domain.,subcellular location:Cytoplasmic bodies.,subunit:Interacts with topoisomerase 1 and with TRIM5 isoform Delta. Interacts with CUL3.,tissue specificity:Ubiquitous; higher levels in heart and skeletal muscle., |
