Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM)
Other Name
Species
Human
Gene ID
84293
Uniprot
Q9BRX8,
Species.1
Mouse
Gene ID.1
70564
Uniprot.1
Q9CYH2,
Species.2
Rat
Gene ID.2
361118
Uniprot.2
Q6AXX6
Cellular Localization
Cytoplasm . Secreted . Secreted from mature adipocytes but not from preadipocytes. .
Tissue Expression
Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs).
Signaling_pathway
Research Areas
Function
Involved in redox regulation of the cell . Acts as an antioxidant . Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation . May affect bone resorption and help to maintain bone mass . Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway .