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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/C1QA Polyclonal Antibody
SKU: WP1037 Categories: ,

C1QA Polyclonal Antibody

Ucallm_WP1037-50

Price range: $268.00 through $328.00

SKU: WP1037-100
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Product details

Background:

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetC1QA
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)26kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-200; ELISA 1:5000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein AA range: 181-230
SpecificityC1QA Polyclonal Antibody detects endogenous levels of protein.
Gene NameC1QA
Protein NameComplement C1q subcomponent subunit A
Other Name
SpeciesHuman
Gene ID712
UniprotP02745,
Species.1Mouse
Gene ID.1
Uniprot.1P98086,
Species.2Rat
Gene ID.2
Uniprot.2P31720
Cellular LocalizationSecreted.
Tissue ExpressionLiver,Monocyte,Plasma,Spleen,
Signaling_pathwayOrganismal Systems >> Immune system >> Complement and coagulation cascades;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Neurodegenerative disease >> Prion disease
Research Areas>>Complement and coagulation cascades; / >>Alcoholic liver disease; / >>Prion disease; / >>Pertussis; / >>Chagas disease; / >>Staphylococcus aureus infection; / >>Coronavirus disease - COVID-19; / >>Systemic lupus erythematosus
FunctionDisease:Defects in C1QA are a cause of C1q deficiency [MIM:120550]. It is a rare genetic disorder which is associated with recurrent infections and a high prevalence of lupus erythematosus-like symptoms. It is characterized by a loss of activation of the complement classical pathway.,Function:C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.,online information:C1QA mutation db,PTM:O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.,similarity:Contains 1 C1q domain.,similarity:Contains 1 collagen-like domain.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.,
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