Name: C8 β Polyclonal Antibody
SKU: WP15761
Price: 268 USD
Availability: InStock

C8 β Polyclonal Antibody

Ucallm_WP15761-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15761-100

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Product details

Background:

This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],

Specifications

Size	50μL/100μL
Target	C8 β
Reactivity	Human, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	70kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:10000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human C8B. AA range:371-420
Specificity	C8 β Polyclonal Antibody detects endogenous levels of C8 β
Gene Name	C8B
Protein Name	C8 β
Other Name	Complement component C8 beta chain; / Complement component 8 subunit beta
Species	Human
Gene ID	732
Uniprot	P07358,
Species.1	Mouse
Gene ID.1	110382
Uniprot.1	Q8BH35,
Species.2	Rat
Gene ID.2
Uniprot.2	P55314
Cellular Localization	Secreted.
Tissue Expression	Liver,Plasma,
Signaling_pathway	Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Complement and coagulation cascades;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Neurodegenerative disease >> Prion disease
Research Areas	>>Complement and coagulation cascades; / >>Prion disease; / >>Amoebiasis; / >>Coronavirus disease - COVID-19; / >>Systemic lupus erythematosus
Function	Disease:Defects in C8B are a cause of complement C8 deficiency type II [MIM:120960]. Patients with deficiency of C8 suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,Function:C8 is a constituent of the membrane attack complex. C8 binds to the C5b-7 complex, forming the C5b-8 complex. C5-b8 binds C9 and acts as a catalyst in the polymerization of C9.,online information:C8B mutation db,polymorphism:The sequence shown is that of allotype C8B B.,PTM:N-glycosylated; contains one or two bound glycans. Not O-glycosylated.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 TSP type-1 domains.,subunit:C8 is composed of three chains: alpha, beta and gamma. The beta chain binds to the C8 alpha chain and to the C5b-C7 complex, presumably to C5b. It is essential to the incorporation of C8 into the C5b-C8 complex.,